Supply:40MG/TAB(SIMETHICONER)
Use:Antiflatulent, relief GI gas pain.
Contraindication:Infant colic.
Adverse effect:None
Usual dosage:Tab: 1-2 Tabs QID, PC & HS. Drops: 2ml QID, PC & HS (shake well before using).
MAGALDRATE
Supply:200MG/TAB(MAGACIDR)
Use:Over-secretion of gastric acid.
Usual dosage:2-4 tab qid
BOWCON R
PIPERILATE 3MG+MAGNESIUM ALUMINUM 295MG
SPAGASTROL R
BUTINOLIN PHOSPHATE 600MGBISMUTH 150MG
BALUNAR
DIHYDROXYALUMINUM SODIUM CARBONATE 350MG
LEDERSCONER
ALUMINUM HYDROXIDE DRIDE GEL334MG ANTIFOAM AF EMULSION 36.7MG
ALUMINUM HYDROXIDE DRIED GEL 200MG SIMETHICONE 20MG
HOMALINR
ALUMINUM HYDROXIDE 299MG
WELLPINR
ALUMINUM HYDROXIDE MAGNESIUM
CARBONATE CO-DRIDE GEL 282MGSIMETHICONE 25MG
H2 receptor antagonists
CIMETIDINE B
Supply:300MG/2ML/AMP(TAGAMETR),400MG/F.C.TAB(TAGAMETR)
Use:Gatric and duodenal ulcer, gastroesophageal reflux, pathological hypersecretory conditions (eg. Zollinger-Ellison
syndrome) , stress related mucosal damage.
Adverse effect:Dizziness, headache, confusional states, diarrhea, rash, gynecomastia, impotence, thrombocytopenia, muscular pain, cardiac arrhythmia.
Usual dosage:Adults: 300mg Q6-8H (IV, IM), 300mg QID (PO) and treated continuously for 4-6 weeks. Max. dose: 2.4gm/day, 12gm/day in hypersecretory condition. Oral 400mg HS for prophylaxis of recurrent ulcer.
Child: 20-40mg/kg/day (Tab, Inj) in divided doses, four times a day.
Dosage adjustment : according to CrCl (ml/min)
> 50 : 300mg Q6H or 300mg QID
20 - 50 : 300mg Q8H or 300mg TID
< 20 : 300mg Q12H or 300mg BID
Special precautions:Impaired renal function; gastric malignancy; hemodialysis; pregnancy, lactation; elderly.
RANITIDINE B
Supply:150MG/F.C.TAB(QUICRANR, WEIDOSR), 25MG/ML/2ML/AMP(VESYCAR), 50MG/5ML/AMP(GETWAYR)
Use:Similar to cimetidine
Contraindication:
Adverse effect:Dizziness, insomnia, rash, arthragia
Usual dosage:Adults: IV, IM : 50mg Q6-8H; PO : 150mg BID or 300mg HS for treatment of duodenal or gastric ulcer; maximum dose: IV 400mg/day, PO 6gm/day; PO 150mg HS for prophylaxis of recurrent ulcer.
Child: Oral, 2-4mg/kg, two times a day up to a maximam dose of 300mg/day. IV, 2-4 mg/kg/day, in divided doses.
Dosage adjustment : according to CrCl (ml/min)
> 50 : 50 mg Q6-8H or 150 mg BID
20 - 50 : 50 mg Q12H or 150 mg HS
< 20 : 50 mg Q24H or 150 mg HS
Special precautions:Renal & hepatic impairment, gastric malignancy.
NIZATIDINE C
Supply:150MG/CAP(TAZAC PULVULESR)
Use:Duodenal ulcers, gastroesophageal reflux disease.
Contraindication:Patients who have a hypersensitivity to other H2-antagonists, should not receive nizatidine since a cross-sensitivity has been observed with this class of drugs.
Adverse effect:Headache is the most common side effect followed by gastrointestinal effects and dizziness.
Usual dosage:150mg BID or 300mg HS
Special precautions:Symptomatic response to nizatidine dose not preclude gastric malignancy; moderate to severe renal insufficiency; pregnancy & lactation.
FAMOTIDINE B
Supply:20MG/F.C.TAB(FAMODINER, VOKERR, WEIMOKR), 20MG/AMP(FORGASR), 40MG/F.C.TAB(WEIMOKR)
Use:Similar to cimetidine.
Contraindication:Hypersensitivity to famotidine or other H2-antagonists
Adverse effect:Headache, dizziness, diarrhea, constipation, arthralgia, somnolence, rash.
Drug interaction:Decreased effect of ketoconazole, itraconazole
Usual dosage:Adults: IV 20mg Q12H, PO 20mg BID or 40mg HS for treatment of duodenal or benign gastric ulcer. PO 20-40mg BID for treatment of GERD. Oral max. dose: 640mg/day. Oral 20 mg HS for prophylaxis of recurrent ulcer. Child: For BW > 10kg : PO 1-2mg/kg/day, in two divided doses. For BW < 10kg : PO 1-2mg/kg/day, in three divided doses.
Dosage adjustment : according to CrCl (ml/min)
> 50 : 20 mg Q6-8H or 20-40 mg BID
20 - 50 : 20 mg Q12H or 20 mg BID
< 20 : 20 mg Q24H or 20 mg HS
Special precautions:Modify dose in patients with renal impairment
Mucosal Protectants
CETRAXATE HCL
Supply:200MG/CAP(NEUERR)
Use:Peptic ulcer.
Adverse effect:Thirst, GI disturbances, fullness in abdomen, exanthema, hypersensitivity.
Usual dosage:200 mg tid-qid.
Special precautions:Thrombosis, consumption coagulopathy;pregnancy.
SUCRALFATE B
Supply:500MG/TAB(WEIZIPR), 1GM/SUSP.PKG(SUCRATE GELR), 1GM/SACHET.PKG(YUWAN-SR)
Use:Short-term management of duodenal ulcers
Unlabeled use: Gastric ulcers maintenance of duodenal ulcers; suspension may be used topically for treatment of stomatitis due to cancer chemotherapy and other cause of esophagel and gastric erosions; GERD, esophagitis; treatment of NSAID mucosal damage; prevention of stress ulcers; postsclerotherapy for esophageal variceal bleeding
Adverse effect:Dizziness, dry mouth, constipation may occur after prolong use.
Usual dosage:Weizip 2 tab tid-qid before meals. Sucrate 1 sachet bib, Maintenance:1 sachet daily. Yuwan-s 1g qid or 2g bid
Patient information:Take before meals or on empty stomach; do not take antacid 30 minutes befor or after taking sucralfate
Mechanism: Forms a complex by binding with positively charged proteins in exudates, forming a viscouse paste-like, adhesive substance. This selectively form a protective coating that protects the lining against peptic acid, pepsin, and bile salts
Antispasmodic drugs
ALVERINE
Supply:60NG/CAP(SPASMONALR)
Use:Dysmenorrhea & pre-menstrual pain; selsctive muscle spasmolytic in conditions eg. Irritable bowel syndrome, painful diverticular disease of the colon.
Contraindication:Paralytic ileus.
Usual dosage:Adult & elderly 1 or 2 cap once-tid.
Special precautions:1st trimester of pregnancy.
CEFATROPIN
Contect: atropine sulfate 0.01 mg , Complex silver compound 0.1 mg, gelsemine extr 0.08 mg
Use:Gastric & duodenal ulcer, gastritis, indigestion, heartburn, pressure, spastic pain in the stomach region.
Usual dosage:1-2 tab tid before meals.
ATROPINE SULFATE
Supply:1MG/1ML(ANTOPINR)
Use:Antisecretory, antispasmodics, treatment of acute poisoning of parasympathomimetic agents.
Contraindication:Prostatic enlargement, paralytic ileus, pyloric stenosis, glaucoma, tachycardia.
Adverse effect:Tachycardia, increasing ocular tension, pupils dilatation, dry mouth, blurred vision, dysurea, headache, weakness, nausea, vomiting, restlessness, rash.
Usual dosage:Anticholinergic: 0.4-0.6mg IV, SC. Preanesthetic medication: 0.3-0.6mg, SC, IM or IV. Antidote of cholinesterase inhibitor: 2-4mg IV then 2mg, every 5-10min, IM, until muscarinic symptoms disappear or atropine toxicity appear.
Supply:1MG/F.C.TAB(DAIPINR)
Use:Spasms & hypermotility of GIT, biliary & renal tract dyskinesia
Contraindication:Dysuria due to prostatic enlargement; paralytic ileus; glaucoma; severe heart diseases.
Adverse effect:Dry mouth, dysphagia thirst; mydriasis with cycloplegia & photophobia; flushing; urinary urgency, difficulty & retention. Occasionally, vomiting, giddiness, staggering.
Usual dosage:Adult 1-2 tab tid-qid
PINAVERIUM BROMIDE
Supply:50MG/F.C.TAB(DICETELR)
Use:Pinaverium is a calcium channel blocking agent (spasmolytic) used for the treatment of gastrointestinal disorders.
Place in therapy: No convincing evidence of the efficacy of pinaverium in treatment of irritable bowel syndrome. And the drug offered no clinically significant advantage over anticholinergics. The efficacy of pinaverium in biliary functional disorders requires further evaluation.
Contraindication:Hypersensitivity to pinaverium bromide or bromides
Adverse effect:The adverse effects of pinaverium include epigastric pain and/or fullness, heartburn, constipation, abdominal distention, dry mouth, headache, and drowsiness.
Usual dosage:Irritable bowel syndrome: 50 mg PO TID; Give with food to minimize irritation of esophageal mucosa.
Special precautions:Pregnancy
PIPETHANATE ETHOBROMIDE
Supply:10MG/S.C.TAB(PETHOR)
Use:Acute gastritis, gastric hypermotility, spasms of urinary tract.
Contraindication:Prostatic enlargement may lead to urinary retention, paralytic ileus; pyloric stenosis; closed-angle glaucoma.
Adverse effect:Dry mouth with difficulty in swallowing & talking; thist; mydriasis with cycloplegia & photophobia; flushing & dry skin; transient bradycardia; occasionally vomiting, giddiness, staggering.
Usual dosage:1-2 tab tid-qid
Special precautions:Diarrhea; myasthenia gravis; fever; tachycardia, cardiac surgery; may cause mental confusion.
PIPOXOLAN
Supply:10MG/F.C.TAB/(ROWAPRAXINR)
Use:Pipoxolan is used as a smooth muscle relaxant.
Contraindication:glaucoma; prostest cancer with urine retention; pregnant women
Adverse effect:No atropine-like toxicity reported. No further data available.
Usual dosage:Adults: vascular type headache: 1 tab PO TID; urinary spasm: 1-3 tab PO TID
Child: age above 6: 1-3 tab PO QD to BID; child age under 6: not recommended
Antidiarrheal drugs
BISMUTH SUBCARBONATE
Supply:324MG/TAB(bismuth subcarbonateR)
Use:Enteritis, dysentery and colitis with diarrhea, astringent.
Contraindication:Renal and hepatic disease, septic-condition of the mouth.
Adverse effect:GI disturbance,anorexia, headache, malaise, skin reaction, discoloration of mucous membranes.
Usual dosage:1-2 Tabs, TID or QID.
POLYCARBOPHIL
Supply:500mg/Tab(MITROLANR)
Use:Calcium polycarbophil is a hydrophilic resin for use in both diarrhea and constipation. Calcium polycarbophil is effective in both constipation and diarrhea and may be useful in sodium-restricted patients
Place in therapy: Calcium polycarbophil is equally effective as psyllium and more effective than kaolin-pectin.
Contraindication:Intestinal obstruction or fecal impaction or swallowing difficulties
Adverse effect:The only significant side effects have been abnormal fullness and flatulence.
Usual dosage:Adult: 2 tab (chewed) PO QID; 250 ml of water is given in constipation;
Child: 3 to 6 y/o: 1 tab PO BID chewed and swallowed with 250 ml of water or other fluid; 6 to 12 y/o: 1 tab PO TID chewed and swallowed with 250 ml of water or other fluid three times
ANTIBIOPHILUS
Content:Per g Lactobacillus acidophilus Lyophillised Lactobacillus casei variety rhamnosus 1.0x108
Use:Prevention of antibiotic-induced diarrhea; symptomatic treatment of diarrhea of a non-organic origin in infant < 2yr: as a complement to rehydration, >2yr:treatment dose not exempt from rehydration if necessary.
Usual dosage: Preventive treatment 2 cap/day. Intestinal transit disorders 4-8 cap/day.
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