SupplyiG200mg/Tab(TEGOLR), 200mg/F.C.Tab(TEGRETOL CRR)
UseiGFor relief of pain associated with trigeminal neuralgia and use to control grand mal and psychomotor or partial seizure.
ContraindicationiGPatients with previous bone marrow depression, hypersensitivity to carbamazepine and with a hisotry of cardiac, hepatic, or renal disease.
Adverse effectiGDizziness, ataxia, drowsiness, nausea, vomiting, agitation, tremor.
Usual dosageiGEpilepsy: initial dose 100-200mg, 1-2 times daily, gradually increased of 200mg/day to a usual maintenance dose of 0.8 to 1.2g daily in 2-4 divided doses up to 1.6g/day. Trigeminal neuralgia: initial dose 100mg BID, increased by 200mg daily up to 1.2g daily, usual maintenance dose 400-800mg daily in 2-4 divided doses.
Tegretol controlled release Tab can be divided into two parts but can not be crashed. For shifting from convensional tablet to controlled release form, increasing of 10-20% dose is recommended. For a 300 mg TID patient, 3 weeks are required for dose shifting to 500 mg CR BID.
Patient informationiGTake with food, may cause drowsiness, periodic blood test monitoring required; notify physician if you observe bleeding, bruising, jaundice, abdominal pain, pale stools, mental distrubances, fever, chills, sore throat, or mouth ulcers
CLONAZEPAM B
SupplyiG2mg/Tab(RIVOTRILR)
UseiGMajority of clinical forms of epileptic disease in infants & children esp typical or atypical petient mal epilepsy, tonic-clonic seizure, status epilepticus. Adult epilepsies & in focal seizures
Adverse effectiGTirdness, sleepiness, lassitude, muscular hypotonia, muscle weakness, dizziness, lightheadedness, ataxia, slowed reaction, poor conc., restlessness, confusion, disorientation; anterograde amnesia, depression. Increased production of saliva or of bronchial secretions in infants & young children
Usual dosageiGAdult 4-8 mg. Child >6 yr 3-6 mg, Small child 1.5-3 mg. Infant 0.5-1 mg. Divided into 3 or 4 doses daily.
PHENYTOIN D
SupplyiG100mg/Cap(DILANTINR), 250mg/5ml/Amp(ALEVIATINR)
UseiG1. Grand mal seizures and psychomotor seizures.
2. Ventricular tachycardia, paroxysmal atrial tachycardia.
3. Digitalis intoxication induced arrhythmias.
ContraindicationiGHypersensitivity to hydantoins, hemopoietic disorders, hepatic disease.
Adverse effectiGDrowsiness, ataxia, diplopia, GI disturbance, gingival hyperplasia, thrombocytopenia, agranulocytosis, osteomalacia.
Usual dosageiG1. Grand mal and psychomotor seizure: Adults: PO, initial dose 100mg TID, increase in dosage to a maximum of 600mg/day, usual maintenance dose: 300-400mg daily. IV, initial dose 150-200mg given at a rate not exceeding 50mg/min. Child: PO, initial dose 5mg/kg/day in 2-3 divided dose, maintenance dose 4-8mg/kg/day. IV, may be given 15-20mg/kg, at a rate not exceeding 1-3mg/kg/min.
2. Cardiac arrhythmias: IV, usual dose 3.5-5mg/kg, given at a rate not more than 50mg/min, electrocardiographic monitoring is recommended.
TOPIRAMATE
SupplyiG100mg/F.C.Tab(TOPAMAXR), 25mg/ F.C.Tab(TOPAMAXR)
UseiGAdjunctive therapy in adults & children greater than or equal to 2 yr with partial seizures, seizures associated with the Lennox-Gastaut Syndrome, as well as tonic-clonic
ContraindicationiGPregnancy
Adverse effectiGAtaxia, impaired conc, confusion, dizziness, faigue, paresthesia, somnolence, abnormal thinking. Less commonly, agintation, dizziness, fatigue, paresthesia, somnolence, abnormal thinking. Less commonly, agitation, amnesia, anorexia, aphasia, depression.
Usual dosageiGAdult 200-600 mg/day in 2 doses. Max:800 mg/day. Child greater than or equal to 2 yr 5-9 mg/kg/day in 2 doses.
VALPROIC ACID D
SupplyiG500mg/Cap(CONVULEXR)
UseiGGeneralized seizures, partial seizures
ContraindicationiGDisturbances of hepatic or pancreatic functions
Adverse effectiGNausea, vomiting, anorexia, increased appetite, weight gain, gastralgia, gastrospasm, diarrhea & constipation. Rarely, sedation, vertigo, headache, depressive deterioration, aggression, involuntary movements, hyperactivity, tonic cramps, ataxia, coordination disturbances, tremor, asterixis, dysarthria, nystagmus, diplopia.
Usual dosageiGInitially 15 mg/kg daily. Dosage should be increased by 5-10 mg/kg/wk, generally up to 30 mg/kg body wt daily.
SOD. VALPROATE
SupplyiG20%/40ml/Bot(DEPAKINER)
UseiGSimple and complex absence seizures, including petit mal.
ContraindicationiGHypersensitivity to valproic acid, hepatic or renal function impairment, blood dyscrasias.
Adverse effectiGNausea, vomiting, GI irritation, drowsiness, ataxia, transient alopecia, liver dysfunction.
Usual dosageiGAdult: Initial dose: 10-15mg/kg/day, increased by 5-10mg/kg daily at one week intervals until seizures are controlled, maximum recommended dosage is 60mg/kg/day. Child: 25-30 mg/kg/day of Depakin chron; Switch from Depakin to Deparkin chrono: in a three-day base from 1500 mg Deparkin to Chrono form, day 0: 500 mg QD of Deparkin, day 1: conventional form 1 Tab QD and chrono 1 Tab TID, day 2: chrono 1 Tab QD and 2 Tabs QN, day 3: chrono 3 Tab QD or QN.
VIGABATRIN
SupplyiG500mg/F.C.Tab(SABRILR)
UseiGVigabatrin is a derivative of gamma-aminobutyric acid that is used as an anticonvulsant. It is an effective adjunctive anticonvulsant for the treatment of multidrug-refractory complex partial seizures in adults. It is also effective in resistant partial seizures and infantile spasms in children and adolescents.
ContraindicationiGHypersensitivity to vigabatrin.
Adverse effectiGHeadache, ataxia, irritablility, behavior changes, anxiety, gastrointestinal disturbance, weight gain, and acute psychosis; psychosis has occurred upon abrupt withdrawal of vigabatrin.
Usual dosageiGAdults:for add-on therapy 2-3 g/day, increase to 4 g daily if necessary Child: 1-2 g/day.
Drugs used for parkinsonism
BIPERIDEN HCL C
SupplyiG2mg/Tab(AKINETONR)
UseiGArteriosclerotic, idiopathic postencephalitic parkin-sonism, drug-induced extrapyrimidal syndrome
ContraindicationiGClosed angle glaucoma, mechanic stenosis of the GI tract, hypersensitivity.
Adverse effectiGDry mouth, dizziness, fatigue, vertigo, gastric upset, mental confusion, transient postural hypotension.
Usual dosageiGPO 2mg TID or QID, PC.
*SINEMET25/250 C
ContentiGCARBIDOPA 25MG, L-DOPA 250MG
UseiGlisted in dosage
ContraindicationiGNarrow-angle glaucoma. Undiagosed skin lesions or history of melanoma. Hypersensitivity to any component of this product
Adverse effectiGDyskinesia including choreiform, dystonic & other involuntary movements. Mental changes including paranoid ideation & psychotic episodes; depression, development of suicidal tendencies;dementia; & GI disturbances.
Usual dosageiGSymptomatic treatment of Parkinsonism 1/2tab once or bid. Max:8 tab. Transfer from L-Dopa Stop L-Dopa therapy 12 hr befor Sinement 25/250 is started therapy
*MADOPAR
ContentiGCap:L-Dopa 100mg, Benserazide25mg
Tab: L-Dopa 200mg, Benserazide50mg
UseiGSymptomatic (postencephalitic, toxic or arterio-sclerotic) parkinsonism, except drug-induced parkinsonism, parkinson's disease.
ContraindicationiGSeverely decompensated endocrine, renal, hepatic, cardiac disorders; psychosis and severe psychoneurosis; patient under 25 years old; pregnant women. No MAO inhibitors should be used concomitantly.
Adverse effectiGAnorexia, nausea, and vomiting, psychic disturbance.
Usual dosageiGInitial dose: 125mg TID then increased by 125mg weekly until the individual therapeutic dosage is reached up to 1.25g/day QID.
Pharmacokinetics: The bioavailablilty of Madopar HBS is 60% to those of conventional form. After ingestion HBS form need 3 hours to achieve serum peak concentration.
Note:The effects of levodopa are reduced or abolished by the concurrent use of vitamin B6 but no interaction occures with levodopa-carbidopa or levodopa-benserazide preperation.
PERGOLIDE B
SupplyiG50mcg/Tab(CELANCE 50R)
UseiGDopamine agonist, used as adjunct therapy with levodopa/carbidopa in long-term parkinsonian patients with clinical fluctuations. It is also effective in the treatment of hyperprolactinemia and acromegaly.
ContraindicationiGDisplayed hypersensitivity or idiosyncratic reactions to this drug or other ergot derivatives.
Adverse effectiGDyskinesias, dystonias, orthostatic hypotension, dizziness, confusion, somnolance, insomnia, nausea, constipation; CNS complain is most commonly hallucinations (8%) and confusion (2%) are the primary cause for drug withdrawal.
Usual dosageiGIn hyperprolactinemic and acromegalic patients: 0.025 to 0.5 mg/day, PO. In Parkinson's disease: 2 to 3 mg, up to 10 mg/day in divided doses.
SELEGILINE C
SupplyiG5mg/Tab(SILTINR)
UseiGSelegiline is a monoamine oxidase (MAO) inhibitor that is specific for the MAO-B isozyme. It is effective in treating parkinsonian patients who develop fluctuations in response to chronic levodopa therapy and require maximum doses of the drug. The agent will allow lower doses of levodopa either alone or in combination with peripheral decarboxylase inhibitors. Selegiline may also be effective in delaying the need to initiate levodopa therapy in the early stage of Parkinson's disease. Selegiline has also shown some benefit in the treatment of Alzheimer's disease.
ContraindicationiGSelegiline is contraindicated for use with meperidine and patient with hypersensitivity to the drug.
Adverse effectiGSleep disturbances, psychosis, agitation, confusion, and dyskinesias, hypotension, anorexia, and increased libido; the adverse effects of agitation, confusion, and insomnia may occur more frequently in the elderly.
Usual dosageiGParkinsonism: PO 5-10mg QD; Depression: PO 5-30mg, QD. The doses should not exceed 10mg/day because of the risks associated with non-selective inhibition of monoamine oxidase (MAO).
TRIHEXYPHENIDYL HCL C
SupplyiG2mg, 5mg/Tab(BENZHEXOLR)
UseiGParkinsonism, extrapyramidal disorders due to reserpine & phenothiazine, muscle rigidity.
ContraindicationiGClosed angle galucoma, paralytic ileus or pyloric stenosis, prostatic enlargement.
Adverse effectiGDry mouth, fatigue, vertigo, gastric upset, psychotic disturbance
Usual dosageiGUsual dose 2mg TID or QID. Maximum dose: 15mg/day
Patient informationiGTake after meals or with food if GI upset occurs; do not discontinue drug abruptly; notify physician if adverse GI effects, rapid or pounding heartbeat, confusion, eye pain, rash, fever or heat intolerance occurs. Observe caution when performing hazardous takes or those that require alertness such as driving, as may cause drowsiness. Avoid alcohol and other CNS depressants. May cause dry mouth-adequate fluid intake or hard sugar free candy may relieve. Difficult urination or constipation may occur notify physician if effect persist; may increase susceptibility to heat stroke.
Skeletal muscle relaxants
BACLOFEN C
SupplyiG5mg/Tab(BACLOFENR)
UseiGTreatment of spasicity resulting from spinal crod & cerebral disease/injuries
Adverse effectiGSedation, dizziness, weakness, tiredness, CNS disturbances, hypotension. Rare resp difficulty, palpitations, chest pain, giddiness, GI disturbances, frequency of micturition. Skin reactions
Usual dosageiGInitially 5 mg tid for 3 days. Addition of 5 mg/dose every 3 days. Dose range:40-80 mg daily
Special precautionsiGRenal impairment. Pregnancy, lactation. Children <12yr. May impair ability to drive or operate machinery
SupplyiG200mg/Tab(DORSIFLEXR)
UseiGAll pain of vertebral origin or due to muscular spasm, which is often chronic.Torticollis, muscular rheumatism, muscular pain, cervical syndrome, pain due to extension, arthritis, spasm of the skeletal musculature.
Usual dosageiGAdults:1-2 tablets three times daily. Child of 6 to 15 years: 1/2 tablet three times with daily meal
SupplyiG2mg/ml 2ml/Amp(PAVULONR)
UseiGAn adjunct to anesthesia to induce skeletal muscle relaxation, to facilitate the management of patients undergoing mechanical ventilation.
ContraindicationiGHypersensitivity to the drug or to the bromide.
Adverse effectiGProfound and prolonged skeletal muscle relaxation resulting in respiratory insufficiency or apnea, slight increase in pulse rate; salivation, wheezing.
Usual dosageiGAdults: Initial IV dosage range is 0.04-0.1ml/kg, later increment dose starting at 0.01mg/kg may be used. For endotracheal intubation: 0.06-0.1mg/kg. Child: The same as for adults. Neonates: A test dose of 0.02mg/kg be given first to measure responsiveness.
Special precautionsiGPre-existing pulmonary, renal disease; pregnancy & neonate acidosis; severe electrolyte disturbances
TOLPERISONE HCL
SupplyiG150mg/Tab(MYDOCALMR)
UseiGSpastic paralysis due to sequelae of stroke, cerebral palsy, SMON, spastic spinal paralysis, amyotrophic lateral sclerosis, cerebrospinal degeneration, multiple sclerosis, cervical spondylosis, sequelae to injury and operation, ossification of the posterior longitudinal ligament.
ContraindicationiGHepatic disease, hypersensitivity, used with caution when administered in conjuction with methocarbamol.
Adverse effectiGHepatic dysfunction, chest distress, respiratory disorder, weakness, lassitude, dizziness, headache, drowsiness, anorexia, abdominal pain, gastric and abdominal discomfort, nausea, vomiting, diarrhea, thirst, constipation, meteorism, sensation of gastric and abdominal distension, gastric oppression and pyrosis.
Usual dosageiGAdults: PO 300mg daily, divided into 3 equal parts.
Antivertigo drugs
PROCHLORPERAZINE C
SupplyiG5mg/Tab(NOVAMINR)
UseiGNausea, vomiting, excessive anxiety, relatively mild psychiatric conditions & moderate to severe psychiatric conditions.
ContraindicationiGComa, drug-induced CNS depression, bone marrow depression.
Adverse effectiGExtrapyramidal symptoms, CNS depression, deep sleep, coma, agitation, convulsions, hypotension, restlessness.
Usual dosageiGNausea & vomiting Adult 1 tab 1-4 times daily. Schizophrenia Adult 3-9 tab in 3 divided doses.
DIPHENIDOL
SupplyiG25mg/S.C.Tab(SINPHADOLR)
UseiGDiphenidol is an antiemetic agent. It may be used to treat nausea and vomiting or vertigo.
ContraindicationiGPatient who has hypersensitivity to the drug. Use with caution to those patient with glaucoma, GI obstruction, or GU disease.
Adverse effectiGThe most serious side effects are hallucinations, confusion, and disorientation. Diphenidol should only be administered to patients in the institutional setting.
Usual dosageiG25-50mg Q4H; diphenidol should not be used in child weighing less than 23kg.
DOMPERIDONE
SupplyiG10mg/Tab(MOTILIUMR)
UseiGDomperidone is a peripheral dopamine antagonist. It has been used in delayed gastric emptying, nausea and vomiting, gastroesopageal reflux disease, and miscellaneous indications.
ContraindicationiGHypersensitivity.
Adverse effectiGGalactorrhea, seizures, and cardiac arrhythmias have been reported.
Usual dosageiGFor nausea and vomiting, oral 20-30mg TID to QID.
For postprandial dyspepsia, oral 10mg TID 15 to 30 minutes before meals.
MECLIZINE B
SupplyiG25mg/Tab(BONAMINER)
UseiGPrevention and treatment of motion sickness and for the relief of allergic states, postoperative vomiting, drug induced nausea and vomiting.
ContraindicationiGHypersensitivity to meclizine, pregnancy.
Adverse effectiGDry mouth, dizziness, blurred vision, fatigue.
Usual dosageiGFor motion sickness: 25-50 mg should be taken 1 hour before travel. For severe nausea and vomiting: 25-50 mg BID or TID.
Special precautionsiGGlaucoma or prostatic enlargement. Avoid driving a car or operating machinery. Pregnancy
Now: 
