SupplyiG30mg/Tab(CODEINER)
UseiGFor relief of mild to moderate pain and cough.
ContraindicationiGRespiratory depression, convulsive disorders.
Adverse effectiGDizziness, euphoria, dysphoria, nausea, vomiting, constipation, pruritus.
Usual dosageiGAdults: analgesic: 15-60mg Q4H, antitussive: 10-20g Q4-6H, do not exceed 120mg in 24 hours. Child: analgesic: 3mg/kg/day in 6 divided doses, antitussive: 2.5-10mg Q4-6H, do not exceed 60mg in 24 hours.
FENTANYL CITRATE C
SupplyiG25mg/Pkg(DUROGESICR), 50mcg/ml(FENTANYLR)
UseiG1. For analgesic action of short duration during the anesthetic periods, premedication, induction, maintenance and in the immediate post operative period. 2. Administration with droperidol as an anesthetic medication and induction.
ContraindicationiG1. Patient with known intolerance to the fentanyl and patient with asthma or myasthenia gravis. 2. In patients who have received MAO inhibitors within 14 days is not recommended.
Adverse effecti¡GRespiratory depression, apnea, muscular rigidity, bradycardia, hypotension, dizziness, blurred vision.
Usual dosageiGPremedication: 0.05-0.1mg IM. Induction: 0.05-0.1mg IV. Maintenance: 0.025-0.05mg IV or IM. Postoperative: 0.05-0.1mg IM.
MORPHINE B
SupplyiG10mg/ml(MORPHINER), 30mg/Tab(MORPHINER)
UseiGRelief of visceral pain, preanesthetic medication.
ContraindicationiGRespiratory depression, biliary colic, acute pancreatitis, asthma and increased intracranial pressure.
Adverse effectiGDizziness, sedation, euphoria, dysphoria, dry mouth, respiratory depression, weakness.
Usual dosageiGSC or IM : Adults: 5-20mg/70kg, child: 0.1-0.2 mg/kg/dose. IV : Adults: 2.5-15mg in 4-5ml water for injection, inject slowly over a 4-5 min period. Oral : peak serum level 2-3 hours.
PETHIDINE B
SupplyiG50mg/ml(DEMEROLR)
UseiGRelief of pain, preoperative medication anesthesia support.
ContraindicationiGHypersensitivity to meperidine, patient who have received MAO inhibitors within 14 days, increased intracranial pressure.
Adverse effectiGDizziness, sedation, euphoria, dysphoria, dry mouth, respiratory depression, weakness.
Usual dosageiGRelief of pain: Adults: 50-150mg IM or PO Q3-4H. Child: 1.1-1.8mg/kg IM, PO or SC up to adult dose Q3-4H. Preoperative medication: Adults: 50-100mg IM 30-90min before anesthesia. Child: 0.5-1mg/lb IM up to adult dose, 30-90min before anesthesia.
Non-narcotic analgesics
ACEMETACIN
SupplyiG60MG/CAP(ACEMETR, ACEOR)
UseiGPain & inflammation in rheumatic disease &other musculoskeletal disorders. Post-op analgesia.
ContraindicationiGHistory of hypersensitivity to aspirin or other NSAIDs. Renal, cardiac or hepatic impairment. Acutive peptic ulceration. Pregnancy. Child, elderly
Adverse effectiGGI disturbance, headache, dizziness, Symptoms of epilepsy. Parkinson's disease &psychiatric disorders may be intensified.
Usual dosageiG1-2 cap tid
Special precautionsiGHistory of gastric or duodenal ulcers. May impair ability to drive or operate machinery.
DICLOFENAC SOD. B
SupplyiG12.5MG/SUPP(VALTAFENR),100MG/S.R.TAB(GROFENACR),
25MG/F.C.TAB(FLAMQUITR),50MG/E.M.CAP(VORENR),
50MG/2ML/AMP(VORENR)
UseiGAn analgesic, antipyretic, anti-inflammatory agent used in rheumatoid arthritis and related disorders.
ContraindicationiGPeptic ulcer and hypersensitivity to NSAIDs, asthma.
Adverse effectiGGI disturbance, diarrhea.
Usual dosageiGAdults: PO 100-150mg/daily, TID or QID. Child age 1 year or over should be given PO 0.5-3mg/kg/day in 2-3 doses. Suppositories: adult 75-100mg daily bid-tid. child 0.5-1 mg/kg/day.
Special precautionsiGAcute disease. Elderly, young child. Hepatic impairment, hypertension, fluid retention. Prepnancy laction. Prolonged use.
SupplyiG20mg/ml120ml/Bot Susp.(SCONINR),600mg/Tab(RECLOFENR)
UseiGRA, osteoarthrosis
ContraindicationiGActive or severe peptic ulceration; asthma or alleragy provoked by aspirin or other NSAID
Adverse effectiGGI effects including ulceration; headache, nervousness; depression; drowsiness; insomnia; blurred vision; rashes; bronchospasm. Rarely, thrombopenia.
Usual dosageiGAdult Initially 1200 mg daily in divided doses. Maintenance: 600-1200 mg daily. May be increased to 1600 mg daily in divided doses. Childn 20 mg/kg body wt daily, <30 kg not >500mg daily
Special precautionsiGPregnancy. Bleeding disorders, CV disease. Renal failure.
KETOPROFEN B
SupplyiG50MG/TAB(KETOPROFENR)
UseiGAnalgesia, antipyresis, anti-inflammatory agent, Dysmenorrhea.
ContraindicationiGHypersensitivity.
Adverse effectiGGI disturbance, peptic ulceration, pruritus, tinnitus,drowsiness, dizziness, headache, anxiety, asthma, agranulocytosis, aplastic anemia, acute renal failure, nephrotic syndrome.
Usual dosageiGRheumatic disorder: PO 150-300mg daily in 3-4 divided doses. Dysmenorrhea, mild to moderate pain: 25-50mg Q 6-8 h as need; IM 50mg BID.
Special precautionsiGCV disease, peptic ulceration, renal failure; elderly
KETOROLAC
SupplyiG10MG/F.C.TAB(KETOR), 30MG/ML/AMP(KETOR)
UseiGFor the short-term management of moderate-sever acute pain, including pain following major abdominal, orthopedic & gynecological operative procedures.
ContraindicationiGHypersensitivity to aspirin or other NSAIDs
Adverse effectiGNausea, abdominal discomfort, peptic ulceration, GI bleeding, drowsiness, dizziness.
Usual dosageiGPO 1 tab 4-6 hrly. IM/IV 6hrly
Special precautionsiGImpaired renal/hepatic function, elderly, childn<16yr.
MELOXICAM
SupplyiG7.5MG/TAB(MOBICR)
UseiGMeloxicam has been effective in the treatment of rheumatoid arthritis and osteoarthritis, comparing well with several other nonstandard anti-inflammatory drugs
Place in therapy: Meloxicam has generally shown comparable efficacy and an improved gastrointestinal tolerability profile when compared to some other nonsteroidal antiinflammatory drugs (ie, diclofenac, piroxicam, naproxen).
ContraindicationiGActive peptic ulceration, severe hepatic insufficiency, non-dialysed severe renal insufficiency, child<15yr, pregnancy & lactation
Adverse effectiGThe adverse effect profile of meloxicam resembles that of other nonsteroidal anti-inflammatory agents but with less gastrointestinal toxicity compared to piroxicam, diclofenac, and naproxen.
Usual dosageiGOsteoarthritis 7.5 mg/day. May be increase to 15 mg/day. RA & ankylosing spondylitis 15 mg/day. May be reduced to 7.5 mg/day. Max: 15m/day
Pharmacokinetics: The oral bioavailability of meloxicam is 89%, and peak serum levels at steady-state occur 5 to 6 hours after administration. Meloxicam is metabolized extensively in the liver; metabolites are excreted in urine and bile. The elimination half-life of meloxicam is about 20 hours after oral doses.
MEPIRIZOLE
SupplyiG100MG/F.C.TAB(MEBRONR)
UseiGAntirheumatic, anti-inflammatory analgesic.
ContraindicationiGPeptic ulcers. Severe hematological abnormalities. Sever hepatic & renal disorder. Hypersensitivity.
Adverse effectiGGI disturbances, stomatitis, dizziness, headache, drowsiness, rash
Usual dosageiG150-450 mg in 2-4 divided doses.
NABUMETONE C
SupplyiG500MG/F.C.TAB(NO-TONR, RELIFEXR)
UseiGNabumetone is a prodrug and has little pharmacologic activity, the metabolite 6-methoxy-2-naphthylacetic acid (6-MNA) is similar to Naproxen. Nabumentone is used for anti-inflammatory and analgesic effects in the symptomatic treatment of acute and chronic osteoarthritis and rheumatoid arthritis.
ContraindicationiGHypersensitivity to Nabumetone, severe hepatic damage, peptic ulcer.
Adverse effectiGDiarrhea, abdominal pain, dyspepsia, nausea, vomiting, rash, headache, dizziness, sedation, peptic ulcer.
Usual dosageiGAdult initial dosage: 1g/daily before sleeping; maintenance dosage: 1~2g/daily, given single or 2 divided doses daily . Elderly: < 1g/daily before sleeping. Due to the extensive hepatic metabolism of nabumetone, no dosage adjusted in patients with renal insufficency is necessary but the inactive metabolites of nabumetone are excred renally. Monitoring of renal function is recommended.
Special precautionsiGHypersensitivity to aspirin, hepatic dysfunction.
NAPROXEN B
SupplyiG250MG/TAB(U-RITISR), 750MG/S.R.TAB(NAPROZENR)
UseiGAnalgesia, antipyresis, anti-inflammatory, acute gout.
ContraindicationiGHypersensitivity, pregnancy women.
Adverse effectiGGI upset, dizziness, headache, tinnitus, constipation, liver function impairment, jaundice, platelet dysfunction, renal function impairment.
Usual dosageiGAdults: initial dose 250mg BID then 500mg-1gm/daily, BID; maximum dose: 1.25g/day; for slow released tablet 750mg QD; acute gout: initial dose 750mg then 250mg Q8H. Childn (over 5 yrs): 10mg/kg/daily BID.
Special precautionsiGPatients with asthma or bronchospasm; bleeding disorders; CV disease; previous or recent peptic ulceration, renal failure or receiving coumarin anticoagulant.
PIROXICAM B
SupplyiG20MG/ML 2ML/AMP(TONMEXR), 20MG//TAB(FOGLUGENR)
UseiGAnalgesia, antipyresis and anti-inflammatory agent.
ContraindicationiGPeptic ulceration, hypersensitivity or sensitivity to aspirin or other NSAIDs, nursing mother.
Adverse effectiGPeptic ulceration, GI bleeding, decreased platelet aggregation and prolonged bleeding time, edema, liver dysfunction, headache, dizziness, drowsiness, fatigue.
Usual dosageiGRheumatic disorders: 10-30mg daily, usual dose 20mg daily. Acute gout: 40mg daily for 5-7 days.
Special precautionsiGImpaired renal function; CV disorders where edema may worsen the condition.
SALICYLAZO SULFAPYRIDINE B
SupplyiG500MG/TAB(SALAZOPYRINR)
UseiGMild to moderate ulcerative colitis , adjunctive therapy in severe ulcerative colitis.
ContraindicationiGHypersensitivity to sulfonamide or salicylates. In infants under 2 yrs, intestinal and urinary obstruction, patients with porphyria.
Adverse effectiGHeadache, blood dyscrasia, skin eruptions, Steven-Johnson syndrome, hypersensitivity reactions.
Usual dosageiGAdult: 3-4g/day divided into 4-8 doses, then 500mg QID (max 8gm/day). Childn: 40-60mg/kg/day in 3-6 divided doses, then 30mg/kg/day divided into 4 doses.
Special precautionsiGHepatic or renal impairment; blood dyscrasia; G6PD deficiency.
SULINDAC B
SupplyiG200MG/TAB(SOLIKYR)
UseiGSymptomatic treatment of acute and chronic rheumatoid arthritis, osteoarthritis and ankylosing spondylitis, acute gouty arthritis.
ContraindicationiGKnown hypersensitivity to the drug and in patients in whom asthma, rhinitis or urticaria is precipitated by aspirin or other NSAIDs.
Adverse effectiGGI pain, dyspepsia, nausea, vomiting, diarrhea and constipation, dizziness, headache, pruritus, sore or dry mucous membrane.
Usual dosageiG150-200mg BID.
Special precautionsiGImpaired hepatic, renal or cardiac function; GI hemorrhage or ulcers; pregnancy.
TENOXICAM
SupplyiG20MG/F.C.TAB(SUTONDINR, TENCAMR)
UseiGTenoxicam is a nonsteroidal anti-inflammatory agent structurally similar to piroxicam. Tenoxicam has been effective in the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and nonarticular rheumatic conditions.
Place in therapy: Available studies have not indicated any significant advantage of tenoxicam over piroxicam (or other NSAIDs) with regard to clinical efficacy for any indication.
ContraindicationiGHypersensitivity , patients with a history of nasal polyps and angioedema or bronchospasm induced by aspirin or other anti-inflammatory agents, caution in patient with upper GI disease.
Adverse effectiGGastrointestinal complaints (nausea, epigastric pain); peptic ulceration has been reported. Other adverse reactions include headache, dizziness, edema, skin rash, and abnormalities in liver and renal function tests. The toxicity profile of tenoxicam is similar to that of piroxicam.
Usual dosageiG20mg IV or IM for 1-2 days then 20mg PO QD; bioavailablility of the drug is reported 100%. And no further accumulation of tenoxicam occurs after 6 months of continuous therapy.
Available one single-dose study suggested that dosage adjustments of tenoxicam are not required in renal insufficiency.
Special precautionsiGRenal disease; diabetes mellitus; liver cirrhosis; depletion. Pregnancy, lactation.
TIAPROFENIC ACID
SupplyiG200MG/CAP(SUFENR)
UseiGRheumatoid arthritis, osteoarthritis, ankylosing spondylitis, soft-tissue rheumatism, sport injuries or trauma.
ContraindicationiGPatients with gastroduodenal ulcer and with a recent history of asthma or urticaria following ingestion of aspirin or other NSAIDs.
Adverse effectiGGI disturbances, renal impairment, urinary disturbances, oedema and fatigue.
Usual dosageiGPO 200mg TID.
TOLFENAMIC ACID
SupplyiG100MG/CAP(CLOTANR)
UseiGAntirheumatic, Anti-inflammatory, Analgesics
Adverse effectiGSlight dysuria; GI complaints, erythema, headache.
Usual dosageiGRheumatic disorders 100-200mg tid. Acute attacks of migraine 200mg when 1st symptoms appear. Repeat after 2-3 hr if satisfactory effect is not obtained. Migrain prophylaxis 100mg tid. Dysmenorrhea 200 mg tid when 1st symptoms of menstruation appear.
Special precautionsiGPeptic & GI ulcers, reduced liver& kidney function.
TOLMETIN SOD. C
SupplyiG200MG/TAB(TOLECTINR)
UseiGRA & osteoarthritis.
ContraindicationiGTolerance. Sensitivity to aspirin & other NSAIDs. Pregnancy & nursing mothers
Adverse effectiGDyspepsia, GI distress, abdominal pain, diarrhea, flatulence, vomiting; headache; asthenia; elevated BP;edema; dizziness; wt gain & loss
Usual dosageiGStarting dose: 400 mg tid, for control: 600-1800 mg daily in divided doses. Control of osteoarthritis: 600-1600 mg daily in divided doses. Child>2yr starting dose:20mg/kg/day in divided doses, for control: 15-30 mg/kg/day
Special precautionsiGImpaired renal function. Compromised cardiac function. Liver dysfunction
GLUCOSAMINE SULFATE
SupplyiG314MG/TAB(VIARTRIL-SR)
UseiGAll form of degenerative osteoarticular disease. Primary & secondary osterarthrosis: cervical arthrosis, coxofemoral arthrosis, gonarthrosis, dorsal arthrosis, Iumbosacral arthrosis, scapulohumeral arthrosis, periarthritis, iumbago, fractures, osteoarticular dystrophies, chronic &subacute arthritis.
Usual dosageiGLight or moderate arthrosic symptoms 2 cap tid for at least 8 wk. Severe arthrosic symptoms Initial therapy:2 cap tid during the 1st 8 wk. Maintenance: 2 cap bid for 3-4mth. Repeat treatment every other 1 yr, depending on patient conditions.
Special precautionsiGVIARTRIL-S is a causal therapy and the therapeutic effect can only be seen after approx. 1 week from the beginning.
Therefore, in case of intense pains it is advisable to take an anti-inflammatory drug in addition during the first days of treatment with VIARTRIL-S
ACETAMINOPHEN C
SupplyiG500MG/TAB(ACETAMINOPHENR, DEPYRETINR, PANAMAXR),100MG/SUPP(ACETAR),24MG/ML60ML(ANTI-PHENR)
UseiGAnalgesic and antipyretic actions similar to aspirin, no anti-inflammatory properties.
ContraindicationiGHypersensitivity to acetaminophen, glucose-6-phosphate dehydrogenase deficiency, continued use in patients with anemia, or with cardiac, pulmonary, renal, or hepatic disease.
Adverse effectiGErythema or urticarial skin reaction, drowsiness, agranulocytosis, liver damage, renal tubural necrosis, methemoglobinemia.
Usual dosageiGAdults: 300-650mg Q4H, up to 1000mg QID, short-term therapy and long-term therapy up to 4g/day. Child: (7-12 yrs): 150-325mg TID or QID, don't exceed 1.3g in 24 hours; (under 6 yrs): 120-200mg TID or QID, don't exceed 480mg in 24 hours.
Special precautionsiGImpaired renal and hepatic function
Drugs used for hyperuricemia and gout
ALLOPURINOL C
SupplyiG100MG/TAB(SYNORIDR),300MG/TAB(APO-ALLOPURINOLR)
UseiGPrimary hyperuricemia of gout, secondary hyper-uricemia due to hematological disorders or antineoplastic therapy, and renal urate stone.
ContraindicationiGHypersensitivity to allopurinol, idiopathic hemochromatosis
Adverse effectiGRash, exfoliative, urticarial or purpuric lesions, nausea, vomiting, agranulocytosis, anemia, peripheral neuritis, diarrhea, headache.
Usual dosageiGInitial dose: 100mg/day PC, then increased by 100mg at weekly interval until serum uric level < 6mg/dl. Maximum dose: 300mg/dose, 800mg/day.
Special precautionsiGAcute gout, liver disease, renal impairment, pregnancy, lactation.
BENZBROMARONE
SupplyiG100MG/TAB(BENRONER, NOGOUTR), 100MG/CAP(BENZROR), 50MG/TAB(BENZONR), 50MG/CAP(NARCARICINR)
UseiGBenzbromarone is a uricosuric used to treat asymptomatic and symptomatic hyperuricemia, gout.
ContraindicationiGRenal dysfunction, glomerular filtration rate is less than 20ml/minute; Benzbromarone therapy should not be initiated during an acute attack of gout.
Adverse effectiGDiarrhea , rash; benzbromarone may precipitate an acute attack of gout and/or uric acid nephropathy. Ensure adequate fluid intake and maintenance of a relatively high urine pH to reduce the risk of nephrolithiasis.
Usual dosageiG40-120mg QD
COLCHICINE C
SupplyiG0.5MG/TAB(COLCHICINER)
UseiGAcute gouty arthritis, chronic sarcoid arthritis.
ContraindicationiGPregnancy, old or feeble patient with cardiac, renal, hepatic & GI disease.
Adverse effectiGNausea, vomiting, abdominal pain, hairless, bone marrow depression, myopathy, peripheral neuritis, burning threat pain, bloody diarrhea, shock, hematuria, oligouria.
Usual dosageiGProphylactic dose: 0.5mg QD-TID. Acute attack of gout: initial dose: 0.5-1mg then 0.5mg Q2H until pain is relieved or nausea, diarrhea appeared.
Drugs used for migraine
DIHYDROERGOTAMINE
SupplyiG5mg/Retard Cap(SEGLORR)
UseiGTreatment of vascular headaches including migraine and cluster headaches, postural hypotension.
ContraindicationiG Peripheral vascular disease, coronary heart disease, hypertension, impaired hepatic or renal function, pregnancy.
Adverse effectiGNausea. Localized edema, itching, transient tachycardia or bradycardia, weakness in the legs, dizziness.
Usual dosageiGPO 1 Cap BID with meals
Special precautionsiGAssociation with josamycin
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